A Multi-Channel Electrochemical Measurement System for Biomolecular Detection

Wei-Chiun LIU  Bin-Da LIU  Chia-Ling WEI  

Publication
IEICE TRANSACTIONS on Electronics   Vol.E99-C   No.11   pp.1295-1303
Publication Date: 2016/11/01
Online ISSN: 1745-1353
DOI: 10.1587/transele.E99.C.1295
Type of Manuscript: PAPER
Category: Electronic Circuits
Keyword: 
3-hydroxyanthranilic acid,  electrochemical,  melatonin,  molecularly imprinted polymers,  nuclear matrix protein 22,  

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Summary: 
A modularized, low-cost, and non-invasive electrochemical examination platform is proposed in this work. Melatonin has been found to be a possible significant indicator molecule in the detection of breast cancer. 3-hydroxyanthranilic acid and nuclear matrix protein 22 can be used as a significant index for potential bladder cancer risks. The proposed system was verified by measuring the melatonin, 3-hydroxyanthranilic acid and nuclear matrix protein 22. Cyclic voltammetry and molecularly imprinted polymers were used in the experiments. Screen-printed electrodes were coated with a film imprinted with target molecules. The measurement results of the proposed system were compared with those of a commercial potentiostat. The two sets of results were very similar. Moreover, the proposed system can be expanded to a four-channel system, which can perform four measurements simultaneously. The proposed system also provides convenient graphical user interface for real-time monitoring and records the information of the redox reactions.