A Novel Double Oscillation Model for Prediction of fMRI BOLD Signals without Detrending

Takashi MATSUBARA  Hiroyuki TORIKAI  Tetsuya SHIMOKAWA  Kenji LEIBNITZ  Ferdinand PEPER  

Publication
IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences   Vol.E98-A   No.9   pp.1924-1936
Publication Date: 2015/09/01
Online ISSN: 1745-1337
DOI: 10.1587/transfun.E98.A.1924
Type of Manuscript: PAPER
Category: Nonlinear Problems
Keyword: 
functional Magnetic Resonance Imaging,  nonlinear dynamical system,  time series prediction,  

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Summary: 
This paper presents a nonlinear model of human brain activity in response to visual stimuli according to Blood-Oxygen-Level-Dependent (BOLD) signals scanned by functional Magnetic Resonance Imaging (fMRI). A BOLD signal often contains a low frequency signal component (trend), which is usually removed by detrending because it is considered a part of noise. However, such detrending could destroy the dynamics of the BOLD signal and ignore an essential component in the response. This paper shows a model that, in the absence of detrending, can predict the BOLD signal with smaller errors than existing models. The presented model also has low Schwarz information criterion, which implies that it will be less likely to overfit the experimental data. Comparison between the various types of artificial trends suggests that the trends are not merely the result of noise in the BOLD signal.