Multimodal Bioimage Sensor

Kazuaki SAWADA  Hirokazu NAKAZAWA  Shoko TAKENAGA  Takeshi HIZAWA  Masato FUTAGAWA  Fumihiro DASAI  Takashi SAKURAI  Koichi OKUMURA  Toshiaki HATTORI  Makoto ISHIDA  

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences   Vol.E97-A   No.3   pp.726-733
Publication Date: 2014/03/01
Online ISSN: 1745-1337
DOI: 10.1587/transfun.E97.A.726
Print ISSN: 0916-8508
Type of Manuscript: INVITED PAPER (Special Section on Analog Circuit Techniques and Related Topics)
bioimaging,  CCD,  pH sensor,  acetylcholine,  ion,  

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To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.