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Multimodal Bioimage Sensor
Kazuaki SAWADA Hirokazu NAKAZAWA Shoko TAKENAGA Takeshi HIZAWA Masato FUTAGAWA Fumihiro DASAI Takashi SAKURAI Koichi OKUMURA Toshiaki HATTORI Makoto ISHIDA
IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences
Publication Date: 2014/03/01
Online ISSN: 1745-1337
Print ISSN: 0916-8508
Type of Manuscript: INVITED PAPER (Special Section on Analog Circuit Techniques and Related Topics)
bioimaging, CCD, pH sensor, acetylcholine, ion,
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To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.