A Proposal of Spatio-Temporal Reconstruction Method Based on a Fast Block-Iterative Algorithm

Tatsuya KON  Takashi OBI  Hideaki TASHIMA  Nagaaki OHYAMA  

IEICE TRANSACTIONS on Information and Systems   Vol.E96-D    No.4    pp.819-825
Publication Date: 2013/04/01
Online ISSN: 1745-1361
DOI: 10.1587/transinf.E96.D.819
Print ISSN: 0916-8532
Type of Manuscript: Special Section PAPER (Special Section on Medical Imaging)
Category: Medical Image Processing
PET,  parametric image,  spatio-temporal reconstruction,  DRAMA,  

Full Text: FreePDF(1.1MB)

Parametric images can help investigate disease mechanisms and vital functions. To estimate parametric images, it is necessary to obtain the tissue time activity curves (tTACs), which express temporal changes of tracer activity in human tissue. In general, the tTACs are calculated from each voxel's value of the time sequential PET images estimated from dynamic PET data. Recently, spatio-temporal PET reconstruction methods have been proposed in order to take into account the temporal correlation within each tTAC. Such spatio-temporal algorithms are generally quite computationally intensive. On the other hand, typical algorithms such as the preconditioned conjugate gradient (PCG) method still does not provide good accuracy in estimation. To overcome these problems, we propose a new spatio-temporal reconstruction method based on the dynamic row-action maximum-likelihood algorithm (DRAMA). As the original algorithm does, the proposed method takes into account the noise propagation, but it achieves much faster convergence. Performance of the method is evaluated with digital phantom simulations and it is shown that the proposed method requires only a few reconstruction processes, thereby remarkably reducing the computational cost required to estimate the tTACs. The results also show that the tTACs and parametric images from the proposed method have better accuracy.

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