A Framework of Ontology-Based Tablet Production Supporting System for a Drug Reformulation

Nopphadol CHALORTHAM  Phuriwat LEESAWAT  Taneth RUANGRAJITPAKORN  Thepchai SUPNITHI  

Publication
IEICE TRANSACTIONS on Information and Systems   Vol.E94-D   No.3   pp.448-455
Publication Date: 2011/03/01
Online ISSN: 1745-1361
DOI: 10.1587/transinf.E94.D.448
Print ISSN: 0916-8532
Type of Manuscript: Special Section PAPER (Special Section on Knowledge Discovery, Data Mining and Creativity Support System)
Category: 
Keyword: 
ontology,  generic drug production,  tablet production supporting system,  drug formulation,  

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Summary: 
This paper presents a framework of supporting system for a drug formulation. We designed ontology to represent the related knowledge for reusable and sharing purposes. The designed ontology is applied with operation rules to suggest an appropriate generic drug production based on information of original drug. The system also provides a validation module to preliminarily approve a pharmaceutical equivalence of the suggested result. Preliminary testing with four random samples shows potential to reformulate a generic product by returning a satisfactory and acceptable of the system suggestions for all samples.