Summary: This paper proposes a combination of novel Received Response (RR) sequence at the transmitter and Matched Filter-Equalizer-RAKE (MF-EQZ-RAKE) combining scheme receiver system for Direct Sequence-Ultra Wideband (DS-UWB) multipath channel model. When binary code sequence such as M sequence is used, there is a possibility of generating extra Inter-Symbol Interference (ISI) in the UWB system. Therefore, it is quite a challenging task to collect the energy efficiently although RAKE reception method is applied at the receiver. The main purpose of the proposed system is to overcome the performance degradation for UWB transmission due to the occurrence of Inter-Symbol Interference (ISI) during high speed transmission of ultra short pulses in a multipath channel. The proposed system improves the system performance by improving the RAKE reception performance using RR sequence and suppressing the ISI effect with the equalizer. Simulation results verify that significant improvement can be obtained by the proposed system especially in UWB multipath channel models such as channel CM4 that suffered severe ISI effect.