Self-Nonself Recognition Algorithm Based on Positive and Negative Selection

Kwee-Bo SIM  Dong-Wook LEE  

Publication
IEICE TRANSACTIONS on Information and Systems   Vol.E87-D   No.2   pp.481-486
Publication Date: 2004/02/01
Online ISSN: 
DOI: 
Print ISSN: 0916-8532
Type of Manuscript: LETTER
Category: Applications of Information Security Techniques
Keyword: 
self-nonself recognition,  immune system,  positive selection,  negative selection,  MHC,  

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Summary: 
In this paper, we propose a self-nonself recognition algorithm based on positive and negative selection used in the developing process of T cells. The anomaly detection algorithm based on negative selection is a representative model among self-recognition method and it has been applied to computer immune systems in recent years. In biological immune systems, T cells are produced through both positive and negative selection. Positive selection is the process used to determine a MHC receptor that recognizes self-molecules. Negative selection is the process used to determine an antigen receptor that recognizes antigens, or nonself cells. In this paper, we propose a self-recognition algorithm based on the positive selection and also propose a fusion algorithm based on both positive and negative selection. To verify the effectiveness of the proposed system, we show simulation results for detecting some infected data obtained from cell changes and string changes in the self-file.