Modeling and Simulation of Fission Yeast Cell Cycle on Hybrid Functional Petri Net

Sachie FUJITA  Mika MATSUI  Hiroshi MATSUNO  Satoru MIYANO  

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences   Vol.E87-A   No.11   pp.2919-2928
Publication Date: 2004/11/01
Online ISSN: 
Print ISSN: 0916-8508
Type of Manuscript: Special Section PAPER (Special Section on Concurrent Systems and Hybrid Systems)
Category: Hybrid Systems
hybrid functional Petri net,  Genomic Object Net,  biological pathways,  cell cycle,  simulation,  

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Through many researches on modeling and analyzing biological pathways, Petri net has recognized as a promising method for representing biological pathways. Recently, Matsuno et al. (2003) introduced hybrid functional Petri net (HFPN) for giving more intuitive and natural biological pathway modeling method than existing Petri nets. They also developed Genomic Object Net (GON) which employs the HFPN as a basic architecture. Many kinds of biological pathways have been modeled with the HFPN and simulated by the GON. This paper gives a new HFPN model of "cell cycle of fission yeast" with giving six basic HFPN components of typical biological reactions, and demonstrating the method how biological pathways can be modeled with these HFPN components. Simulation results by GON suggest a new hypothesis which will help biologist for performing further experiments.