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The Possibility of Magnetic Resonance Imaging-Based Diagnosis of Alzheimer-Type Dementia
Naoki KODAMA Tetsuo SHIMADA Yoshio KOBAYASHI Kei HIWATASHI Isao HIYOSHI Makoto SHIBUKAWA Yasuhiro KAWASE Ichiro FUKUMOTO
IEICE TRANSACTIONS on Information and Systems
Publication Date: 2002/03/01
Print ISSN: 0916-8532
Type of Manuscript: LETTER
Category: Medical Engineering
MRI, DAT diagnosis, hippocampus, ventricle, corpus callosum,
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We studied the possibility of making an objective diagnosis of dementia based on radiological findings by evaluating cerebral and hippocampal atrophy and the corpus callosum shape on MRI images in patients with Alzheimer-type dementia, compared with healthy elderly individuals. There was a statistically significant difference in the hippocampus area index, the ventricle area index, and the area ratio for the second, forth, and fifth parts of corpus callosum. Discriminant analysis using these three parameters demonstrated the sensitivity of 88.5% and the specificity of 85.7%, suggesting a highly positive diagnostic rate. These results indicate that quantitative MRI measurements could be used for differentiating Alzheimer-type dementia from similar diseases.