A Regulation Model of Platelet Production--Simulation Study of Factors Involved in Cyclical Thrombocytopenia--

Chikao UYAMA  Bunji KONDO  Yutaka TAKAHASHI  

IEICE TRANSACTIONS (1976-1990)   Vol.E66   No.11   pp.653-660
Publication Date: 1983/11/25
Online ISSN: 
Print ISSN: 0000-0000
Type of Manuscript: PAPER
Category: Disease Model

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A regulation model of the platelet count was proposed. All the characteristics of the components of the model in the normal state were determined from clinical and experimental results using numerical simulation procedure. Platelet counts of a subject with cyclical thrombocytopenia, measured over a period of 244 days, revealed that the maximum platelet count was 890,000/µl and the minimum count was less than 1000/µl. In addition, nine platelet survival curves were measured within the same period. Analyzing the 9 platelet survival curves, one of the factors causing cyclical thrombocytopenia appeared to be the periodic elevation of the platelet destruction rate. From simulations done under condition that the destruction rate varied cyclically, it was found that the variation rate of peak value of platelet counts was affected by four major parameters of the model. The average daily destruction rate during the period of measurement of survival curves was estimated in such a way that the square error between the estimated and observed curves was made small by adjusting one of the four major parameters. The second factor was found to be a slow variation of the maximum production rate of magakaryocytes (precursor cells of platelets).