A Study on Nonlinear Effect of Modulated Low-Frequency Electromagnetic Waves on Stimulus Response

Hiroki SHINODA  Daisuke ANZAI  Jens KIRCHNER  Georg FISCHER  Jianqing WANG  

Publication
IEICE TRANSACTIONS on Communications   Vol.E102-B   No.6   pp.1097-1103
Publication Date: 2019/06/01
Online ISSN: 1745-1345
DOI: 10.1587/transcom.2018HMP0011
Type of Manuscript: Special Section PAPER (Special Section on Healthcare, Medical Information and Communication Technology for Safe and Secure Society)
Category: 
Keyword: 
low-frequency stimulation,  Frankenhaeuser-Huxley model,  nonlinear response,  On-Off Keying modulation,  

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Summary: 
Stimulus response caused by low-frequency electromagnetic exposure can be used to realize effective medical treatments. However, it is well known that the membrane potential of nerve cells exhibits nonlinearity, particularly in the case of modulated signals, it is important to analyze the nonlinear stimulation effect based on a nerve cell model. This paper adopts the Frankenhaeuser-Huxley (FH) model as the nerve cell model, and evaluates the stimulus response based on the FH model when nerve cells are exposed to low-frequency modulated radio signals such as On-Off Keying (OOK) modulation. This paper investigated the nonlinear effect of the stimulus intensity from the viewpoint of the spike frequency with different modulation parameter values including the induced amplitude and duty cycle. It was confirmed that action potential (AP) rate was higher with OOK-type radio signals than with unmodulated signals.