A Current-Integration-Based CMOS Amperometric Sensor with 1024 × 1024 Bacteria-Sized Microelectrode Array for High-Sensitivity Bacteria Counting

Kohei GAMO  Kazuo NAKAZATO  Kiichi NIITSU  

Publication
IEICE TRANSACTIONS on Electronics   Vol.E100-C   No.6   pp.602-606
Publication Date: 2017/06/01
Online ISSN: 1745-1353
Type of Manuscript: BRIEF PAPER
Category: 
Keyword: 
amperometry,  microelectrode array,  electroless plating,  potentiostat,  

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Summary: 
CMOS amperometric sensors with a microelectrode array offer great potential for counting bacteria because of their low cost, compact size, and ease of use. This paper presents a current-integration-based CMOS amperometric sensor for high-sensitivity bacteria counting. It has a current integrator for noise reduction and reportedly the most large-scale microelectrode array (1024 × 1024). This proposed sensor can count the number of bacteria ranging from a single cell to approximately a million cells. A prototype chip was fabricated using two-poly three-metal (2P3M) 0.6-µm standard CMOS technology. A 7.6 × 7.1-mm2 chip operates from a 5V supply at 1.9mA. In addition, by using the prototype chip, we performed electrochemical measurement and partial 2D imaging of silicone through constant potential amperometry. The measurement results indicate that the proposed sensor chip was able to accurately readout redox current from the 1024 × 1024 sensor array.